International Case Reports Journal (ISSN: 2770-9647) | Volume 4, Issue 1 | Review Article | Open Access
Tuakuila JK*
Katanga AM1, Tuakashikila YM1, Kabamba MM1, Nganga-Nkanga MS2,4, Elongi-Moyene JP3,5, Malumba AM1, Tuakuila JK1,6*
1Faculty of Sciences and Technologies, University of Kinshasa, Kinshasa, DR Congo
2Faculty of Medicine, University of Kinshasa, Kinshasa, DR Congo
3Faculty of Medicine, University of Mbandaka, Equateur, DR Congo
4Marie Biamba-Mutombo Hospital, Kinshasa, DR Congo
5General Hospital of Kinshasa, Kinshasa, DR Congo
6Faculty of Sciences, University of Sherbrooke, Quebec, Canada
*Correspondence to: Tuakuila JK
Fulltext PDFBackground: Thyroid hormones for fetal growth and development are mainly dependent on the stage of pregnancy, especially in the first trimester, requiring the proper maternal thyroid function.
Objectives: To describe the thyroid profile of a hospital-based cross-sectional survey of 100 healthy women living in Kinshasa.
Methods: Mindray chemiluminescence analyzer in detecting Thyroid Stimulating Hormone (TSH), free and total triiodothyronine (FT3, TT3), and free and total thyroxine (FT4, TT4).
Results: The Reference Intervals (RIs) in plasma were proposed as follows: TSH 0.09 to 4.34 μIU/mL, FT3 1.46 to 3.35 pg/mL, FT4 0.62 to 1.25 ng/dL, TT3 0.71 to 2.04 ng/mL, and TT4 7.09 to 17.77 μg/dL. The specific RIs of TSH vs FT4 vs FT3 were respectively 0.22 - 2.66 μIU/mL vs 0.71-1.25 ng/dL vs 0.71-1.59 pg/mL in the first trimester, 0.09 - 4.34 μIU/mL vs 0.62-1.22 ng/dL vs 0.86-2.04 pg/mL in the second trimester, and 0.71-3.40 μIU/mL vs 0.72-0.99 ng/dL vs 0.86-1.66 pg/mL in the third trimester. No subject had hypothyroidism risk, but 6% of subclinical hyperthyroidism prevalence was found.
Conclusions: The findings of this study suggest to undertake a national program extending thyroid function screening as recommended by the American Thyroid Association as well as the European Thyroid Association.
Thyroid stimulating hormone (TSH); Free and total triiodothyronine (FT3, TT3); Free and total thyroxine (FT4, TT4); Gestational population; Kinshasa
Katanga AM, Tuakashikila YM, Kabamba MM, Nganga-Nkanga MS, Elongi-Moyene JP, Malumba AM, Tuakuila JK. Thyroid hormone levels during pregnancy: a hospital-based cross-sectional survey of the healthy gestational population living Kinshasa, DRC. Int Case Rep Jour. 2025;4(1):1-8.