International Case Reports Journal (ISSN: 2770-9647) | Volume 4, Issue 1 | Case Report | Open Access

Paracentral Corneal Ulceration in Secondary Sjogren Syndrome Successfully Treated with Fibrin Glue and Cenegermin: A Case Report

Angelo Macrì^*

Angelo Macrì1*, Margherita Tarallo2, Francesca Cappelli2, Riccardo Scotto2, Luigi Ravazzoni and Michele Iester2

1 IRCCS Ospedale Policlinico San Martino, Genoa, Italy

2Department of Neuroscience, rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy

^*Correspondence to: Angelo Macrì 

Abstract

An 84-year-old woman came to our attention, complaining of decreased visual acuity. The patient was affected by Sjogren syndrome secondary to rheumatoid arthritis for 15 years and developed a paracentral corneal ulcer. The treatment consisted of covering and filling the ulcer with fibrin glue and placing a soft contact lens. Furthermore we started topical treatment with cenegermin eye drop and prophylactic topical antibiotic. In two weeks, we achieved a significant improvement in stromal thickness and resolution of the epithelial defect. After four weeks, we observed an improvement in sensitivity, evaluated with confocal microscopy, which returned to normal after eight weeks. Cenegermin is a powerful therapy aimed at increasing corneal sensitivity and promoting the healing process in severe neurotrophic ulcers also combined with surgical corneal repairing techniques.

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Citation:

Angelo Macrì. Paracentral Corneal Ulceration in Secondary Sjogren Syndrome Successfully Treated with Fibrin Glue and Cenegermin: A Case Report. Int Case Rep Jour. 2025;4(1):1-7.