International Case Reports Journal (ISSN: 2770-9647) | Volume 4, Issue 1 | Case Report | Open Access
Temesgen Assefa Ayele*
Temesgen Assefa Ayele1, Derara Kumela1, Nigus Abebe2 and Rani Seid3
1Department of Internal Medicine, Division of Hematology, St. Peter Hospital, Addis Ababa, Ethiopia
2Department of Internal Medicine, Division of Hematology, St. Paul hospital millennium medical college, Addis Ababa, Ethiopia
3Department of Internal Medicine, Africa medical college, Addis Ababa, Ethiopia
*Correspondence to: Temesgen Assefa Ayele
Fulltext PDFAmyloidosis is a disease characterized by abnormal extracellular deposition of fibrillar proteins in tissues that creates a chronic inflammatory response leading to local tissue injury. The larynx is estimated to be involved in up to 15% of all amyloidosis cases, and accounts for only 1% of all benign laryngeal tumors. Dysphonia is by far the most common primary complaint in laryngeal amyloidosis. A 40 -year-old Ethiopian woman presented with progressively worsening hoarseness of voice of 5 years duration. She had also bilateral knee pain and regurgitation of ingested food over the last 1year. Physical examination, complete blood count, organ function tests, serum electrolyte and other included lab test were unremarkable. Laryngoscopy revealed a 2 cm × 2 cm broad based laryngeal mass and its biopsy result showed an apple-green birefringence, highlighted with a Congo red stain under polarized light microscopy. Kappa free light chain was slightly elevated, & the kappa/lambda ratio was abnormal. This case highlights the significance of high clinical suspicion and histopathology examination in diagnosing such a treatable case.
Amyloidosis; Larynx; Hoarseness; Laryngoscopy; Congo red; Ethiopia
Temesgen Assefa Ayele, Derara Kumela, Nigus Abebe, Rani Seid. Localized Amyloidosis with Elevated Free Light Chain Ratio Presenting as Hoarseness of Voice: A Case Report. Int Case Rep Jour. 2025;4(1):1-5.