1Department of Orthopaedic Surgery, Tri‐Service General Hospital, National Defense Medical Center, Taipei
2Department of Economics, National Chi Nan University, Taiwan
3Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei
4Strategy and Development of Emerging Industries, National Chi Nan University, Nantou 545, Taiwan
The adipose-derived MSCs and Stromal Vascular Fraction (SVF) have been used for many years in autologous regenerative therapies with safe and satisfactory results. The potential use of MSCs, ASCs and related SVF in COVID-19 has been explored extensively due to regeneration and Immunomodulatory effect. The SVF is considered to be an attractive source of stem cells in cell therapy. Besides stem cells, it also contains other functional cells such as macrophages, precursor cells and pericytes. The rationale of the present work is to suggest the possibility to use fast physical sonication method for isolation of autologous SVF with the beneficial characteristics of fast, safe and minimal manipulation. It takes only one hour to complete whole procedures of cell isolation without using enzymes and incubation. Seventy seven years old female, non-smoker with chronic bronchitis for 20 years with pulmonary fibrosis cure using fast physical isolation autologous SVF cells. This treatment is safe with no side effects. It may represent the SVF as a potential therapy in combating COVID-19 induced pulmonary fibrosis.
Pulmonary fibrosis; Chronic lung disease; Chronic asthma; Stromal vascular fraction; Stem cells
Lien-Guo Dai, Mei-Hui Chen MS, Chien-Liang, Chen, Niann-Tzyy Dai. Fast Physical Isolation of Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating COVID-19 Induced Pulmonary Fibrosis. Int Case Rep Jour. 2022;2(1):1-4.