1Department of Pediatrics, INHS Asvini, Mumbai, India 2Department of Pediatrics, INHS Asvini, Mumbai, India, Neonatal Pediatrician, Sidra Medicinne, Doha, Qatar 3Department of Cardiology, INHS Asvini, Mumbai, India 4Department of Nuclear Medicine, INHS Asvini, Mumbai, India 5Department of Medical Oncology, The Royal Hospital, Muscat, OmanFulltext PDF
Anthracyclines and chronic transfusion cause cumulative cardiotoxicity through iron mediated myocardial damage, where early detection could lead to remedial measures. Left Ventricular Ejection Fraction (LVEF) and regional wall motion measurement by Radion uclide Multiple gated Acquisitions (MUGA) scanning is accepted modality to monitor cardiac function in this population. Tissue Doppler Imaging (TDI) offers a sensitive method for earlier detection by assessing myocardial contraction velocity. We compared MUGA & TDI for early detection of cumulative cardiotoxicity.
Thalassemia; Transfusions; Anthracyclines; Cardiotoxicty; Tissue Doppler; Radionuclide Multigated
Kiran More (2021) Comparison of Tissue Doppler Imaging and Radionuclide Multigated Analysis in Assessment of Cumulative Cardiotoxicty to patients receiving Anthracyclines or Multiple Transfusions. Int Case Rep Jour. 1(3):1-10.